- Rage
- Rayman 3 HD
- Rayman Origins
- Red Dead Redemption
- Red Faction: Battlegrounds
- R-Type Dimensions
- Runner 2
- Sacred 3
- Sacred Citadel
- Saints Row IV
- Sam & Max: Beyond Time & Space
- Sam & Max Save the World
- Samurai Shodown II
- Sega Vintage Collection: Alex Kidd & Co.
- Sega Vintage Collection: Monster World
- Sega Vintage Collection: Streets of Rage
- Shadow Complex
- Shank 2
- Shred Nebula
- Silent Hill: Downpour
- Skullgirls
- Small Arms
- Sonic & All-Stars Racing Transformed
- Sonic & Knuckles
- Sonic CD
- Sonic The Fighters
- Sonic The Hedgehog
- Sonic The Hedgehog 2
- Sonic The Hedgehog 3
- Sonic The Hedgehog 4: Episode 1
- Sonic The Hedgehog 4: Episode II
- Soulcalibur
- Soulcalibur II XBox One Edition
- South Park: The Stick of Truth
- Space Giraffe
- Spelunky
- Splosion Man
- SSX
- Star Wars: The Force Unleashed
- Star Wars: The Force Unleashed II
- Super Meat Boy
- Supreme Commander 2